Love, with its fear, exhilaration and transcendence, is perhaps the most enduring subject in the literature of the world. About 11 o'clock on a late August night in Manhattan, Bill stops by his local Blockbuster, and in the nearly vacant shop meets an exotic stranger looking for advice on which movie to rent. In their fragmented and awkward first conversation, they exchange phone numbers and she rides away on her bicycle with a copy of Jules and Jim.

"At two that morning my phone rang. The machine answered; it was Irina saying how much she liked the movie." Not long after, they meet and soon begin a love affair, filled with tension and tenderness, as they navigate through their separate pasts to find a road to travel together, for as long as their fates allow. Madly is a story of accident and inflected passion, of disruption, erotic and doomed. As Bill comes to realize Irina's disturbed, tenuous hold on reality, his own hold on Irina turns relentless and obsessive.