Jimmie Aussapile, Lovina Marcou and Heck Sinclair are members of a secret society dedicated to protecting those who travel America's highways from the monsters, both supernatural and mundane, that lurk in the darkness just beyond your headlights. They are the Brotherhood of the Wheel.

At home in Lenoir, North Carolina, Jimmie and his squire Heck find themselves drawn into an all out war between two competing biker gangs. One is led by a rival biker in possession of new found supernatural allies and the other is an all-female werewolf pack.

Meanwhile, Lovina is drawn into a missing-person case that leads to a Pennsylvania trailer park seemingly haunted by killer clowns.

One way or another peace must be maintained and the many roads of America must be protected. But it might just cost the Brotherhood their souls if they aren't careful.