In this book, the authors first present an overview of the challenges and issues facing MAC and routing in multi-hop wireless networks with beamforming antennas. Subsequently, we discuss various MAC and routing protocols that are specifically designed to address those issues and hence exploit the benefits of beamforming antennas. We also present a framework to provide Quality of Service (QoS) in contention-based wireless networks with beamforming antennas. Finally, we conclude the book with a discussion on open research topics.