This handbook is a practical guide covering pertinent topics in the specialty of Oral Medicine, which focuses on the diagnosis, prevention, and management of local and systemic conditions affecting the oral and maxillofacial region. Each topic covers a specific disease or disorder with overarching emphasis on diseases presenting with oral mucosal involvement and orofacial pain conditions. Each topic is presented as a summary of key clinical information for quick reference prepared by leading experts in the field. This clinical guide will serve as a valuable resource for students and clinicians in practice.