This book gathers high-quality peer-reviewed research papers presented at the International Conference on Intelligent Computing and Networking (IC-ICN 2021), organized by the Computer Department, Thakur College of Engineering and Technology, in Mumbai, Maharashtra, India, on February 26–27, 2021. The book includes innovative and novel papers in the areas of intelligent computing, artificial intelligence, machine learning, deep learning, fuzzy logic, natural language processing, human–machine interaction, big data mining, data science and mining, applications of intelligent systems in health ,care, finance, agriculture and manufacturing, high-performance computing, computer networking, sensor and wireless networks, Internet of Things (IoT), software-defined networks, cryptography, mobile computing, digital forensics, and blockchain technology.