The aim of treatment for chronic myeloid leukaemias may be relief of symptoms and, therefore, improved quality of life, prolongation of life or cure. Treatment modalities are disease specific and include chemotherapy, immune modulation, molecularly targeted therapy and haemopoietic stem cell transplantation. This highly illustrated guide provides a review of the six key types of chronic myeloid leukaemias, discussing clinical features, diagnosis, differential diagnosis, prognosis and treatment. It provides a concise and invaluable overview for haematologists, oncologists and clinical scientists.