This comprehensive Handbook presents an extensive overview of empirical and conceptual developments in the study of high-tech entrepreneurs from an interdisciplinary and multinational perspective. The expert contributors explore various conceptual frameworks and definitions of high-tech entrepreneurs and of the entrepreneurial process based on studies in different settings and contexts. They examine issues of equality, diversity and inclusion in terms of gender and class. The Handbook investigates strategies for empowering high-tech entrepreneurs, ranging from structural conditions and support mechanisms afforded by state and institutional actors, to individual mechanisms used by serial entrepreneurs to avoid burnout. Including unique perspectives on theory and research, this Handbook will make a rigorous and innovative contribution to academics, students and researchers’ understanding of high-tech entrepreneurs.