Large intracranial lesions are among the most complex and dangerous lesions encountered by neurosurgeons, and a single neurosurgical approach often does not provide a large or safe enough corridor for effective treatment. A combined approach to these surgeries, incorporating open, endoscopic, vascular and keyhole techniques can be more successful. This comprehensive text describes in detail how to select the most appropriate approaches, as well as how to avoid any complications that may arise. High quality videos of the techniques described are available through an online version on Cambridge Core, accessible via the code printed on the inside of the cover. With over 150 colour images supporting the text, this is a definitive reference for anyone involved in intracranial tumor or vascular surgery.