This volume covers data describing the role of free radicals and antioxidants that deal with clinical and pre-clinical trials, as well as basic research in the area of women's health.  There is increasing evidence that oxidative stress is a causative, or at least a supporting factor in female pathology and infertility.  During advancing gestational age, oxidative stress biomakers rise.  Oxidative stress plays a regulatory role in transcription, signal transduction, gene expression and membrane trafficking.  A search on Pub Med shows 449 papers have been published to date related to women's health disorders and use of antioxidants in a variety of disease that are prevalent in women, such as hypertension and cardiovascular disease, osteoporosis, obesity and restless leg syndrome.