This anthology, Urban Planning and Design for Megacities in the Global South: Smart and Sustainable Development, sheds light on the intricate dynamics of megacity growth in the Global South. It has compiled a rich and diverse array of evidence-based case studies, fostering discussions on emerging issues, strategies, and solutions for the enhanced planning and development of megacities in the Global South. By delving into the underlying factors propelling this rapid urban expansion, such as economic opportunities, rural-to-urban migration, and natural population growth, this volume analyzes the complex interplay of socio-economic, environmental, and political forces shaping city-regional landscapes. Examining the growth of megacities offers invaluable insights into the challenges and opportunities associated with urbanization in the 21st century. Furthermore, some cities that have not yet achieved megacity status have also been included in this book to provide a comprehensive understanding of urban growth dynamics and the related factors influencing this growth. By studying these rapidly expanding cities, their challenges in urban planning and policy implementation can be identified. These challenges often include inadequate infrastructure, insufficient public services, environmental degradation, and socio-economic disparities. In response, using case studies, the book presents conceptual and empirical strategies to tackle the various problems faced by megacities of the Global South.