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Tomasz Urzykowski | Akateeminen Kirjakauppa

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The Evaluation of Surrogate Endpoints
Tomasz Burzykowski; Geert Molenberghs; Marc Buyse
Springer-Verlag New York Inc. (2005)
Kovakantinen kirja
138,50
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The Evaluation of Surrogate Endpoints
Tomasz Burzykowski; Geert Molenberghs; Marc Buyse
Springer-Verlag New York Inc. (2010)
Pehmeäkantinen kirja
112,40
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ostoskoriin kpl
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Przewodnik po powstanczej Warszawie
Tomasz Urzykowski; Jerzy S. Majewski
Swiat Ksiazki (2012)
Pehmeäkantinen kirja
43,60
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ostoskoriin kpl
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Spacerownik warszawski 1
Dariusz Bartoszewski; Tomasz Urzykowski; Jerzy S. Majewski
Agora (2013)
Pehmeäkantinen kirja
40,80
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ostoskoriin kpl
Siirry koriin
Spacerownik warszawski 2
Jerzy S. Majewski; Dariusz Bartoszewski; Tomasz Urzykowski
Agora (2013)
Pehmeäkantinen kirja
40,80
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ostoskoriin kpl
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Linear Mixed-Effects Models Using R - A Step-by-Step Approach
Andrzej Gałecki; Tomasz Burzykowski
Springer-Verlag New York Inc. (2013)
Kovakantinen kirja
126,80
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ostoskoriin kpl
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Przewodnik po powstanczej Warszawie
Jerzy S. Majewski; Tomasz Urzykowski
Swiat Ksiazki (2014)
Pehmeäkantinen kirja
41,90
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ostoskoriin kpl
Siirry koriin
Linear Mixed-Effects Models Using R - A Step-by-Step Approach
Andrzej Gałecki; Tomasz Burzykowski
Springer-Verlag New York Inc. (2015)
Pehmeäkantinen kirja
88,20
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ostoskoriin kpl
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Spacerownik po warszawskich cmentarzach
Jerzy S. Majewski; Tomasz Urzykowski
Agora (2016)
Pehmeäkantinen kirja
39,60
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ostoskoriin kpl
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Spacerownik. Palac Kultury i Nauki. Socrealistyczna Warszawa
Jerzy S. Majewski; Tomasz Urzykowski
Agora (2015)
Pehmeäkantinen kirja
43,50
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ostoskoriin kpl
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Applied Surrogate Endpoint Evaluation Methods with SAS and R
Ariel Alonso; Theophile Bigirumurame; Tomasz Burzykowski; Marc Buyse; Geert Molenberghs; Leacky Muchene; Nolen Perualila
Taylor & Francis Inc (2016)
Kovakantinen kirja
99,00
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Explanatory Model Analysis - Explore, Explain, and Examine Predictive Models
Przemyslaw Biecek; Tomasz Burzykowski
Taylor & Francis Ltd (2021)
Kovakantinen kirja
146,40
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ostoskoriin kpl
Siirry koriin
Applied Surrogate Endpoint Evaluation Methods with SAS and R
Ariel Alonso; Theophile Bigirumurame; Tomasz Burzykowski; Marc Buyse; Geert Molenberghs; Leacky Muchene; Nolen Perualila
Taylor & Francis Ltd (2020)
Pehmeäkantinen kirja
63,40
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ostoskoriin kpl
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Explanatory Model Analysis - Explore, Explain, and Examine Predictive Models
Przemyslaw Biecek; Tomasz Burzykowski
Taylor & Francis Ltd (2022)
Pehmeäkantinen kirja
63,40
Tuotetta lisätty
ostoskoriin kpl
Siirry koriin
The Evaluation of Surrogate Endpoints
138,50 €
Springer-Verlag New York Inc.
Sivumäärä: 410 sivua
Asu: Kovakantinen kirja
Painos: 2005
Julkaisuvuosi: 2005, 28.02.2005 (lisätietoa)
Kieli: Englanti
Tuotesarja: Statistics for Biology and Health
Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the "true" endpoints of primary interest. Regulatory agencies around the globe, particularly in the United States, Europe, and Japan, are introducing provisions and policies relating to the use of surrogate endpoints in registration studies. But how can one establish the adequacy of a surrogate? What kind of evidence is needed, and what statistical methods portray that evidence most appropriately?


This book offers a balanced account on this controversial topic. The text presents major developments of the last couple of decades, together with a unified, meta-analytic framework within which surrogates can be evaluated from several angles. Methodological development is coupled with perspectives on various therapeutic areas. Academic views are juxtaposed with standpoints of scientists working in the biopharmaceutical industry as well as of colleagues from the regulatory authorities.


Tomasz Burzykowski is Assistant Professor of Biostatistics at the Limburgs Universitair Centrum in Belgium. Dr. Burzykowski has published methodological work on the analysis of survey data, meta-analyses of clinical trials, and validation of surrogate endpoints. He is a co-author of numerous papers applying statistical methods to clinical data in different disease areas (cancer, cardiovascular diseases, dermatology, orthodontics).





Geert Molenberghs is Professor of Biostatistics at the Limburgs Universitair Centrum in Belgium. Dr. Molenberghs published methodological work on surrogate markers in clinical trials, categorical data, longitudinal data analysis, and on the analysis of non-response in clinical and epidemiological studies. He serves as Joint Editor for Applied Statistics (2001-2004) and is President of the International Biometric Society (2004-2005). He was elected Fellow of the American Statistical Association and received the Guy Medal in Bronze from the Royal Statistical Society.


Marc Buyse founded the International Drug Development Institute in 1991. He is Past President of the International Society for Clinical Biostatistics, Past President of the Quetelet Society, and Past Board Member of the Society for Clinical Trials. He is currently the Executive Director of IDDI (International Drug Development Institute) and Associate Professor of biostatistics at the Limburgs Universitair Centrum, Center for Statistics, Diepenbeek, Belgium. He has published extensively in the fields of biostatistics and oncology. His research interests include meta-analysis, surrogate endpoints, statistical detection of fraud, and the design and statistical analysis of clinical trials.





From the reviews:


"A strength of this book is its comprehensive and up-to-date presentation of issues pertinent to the evaluation of surrgoate endpoints...This book makes an important contribution to the clinical trials literature..." Journal of Biopharmaceutical Statistics, 2006


"Many of the chapters deal with real-life data examples and studies involving surrogate outcomes, many written by authors who were directly involved in these studies...The editors have written nice background sections...until a more concise manuscript on this topic is written, this book will remain the most important resource for biostatisticians and researchers in this area." Debajyoti Sinha for the Journal of the American Statistical Association, December 2006


"This book is a reflection of the ongoing debate on the definition and use of surrogate markers...I see the book as an invitation to join the debate. There is much work to be done and reading the book might inspire many to participate. It will be useful for researchers in this and related fields, such as joint modeling of longitudinal and survival data and multivariate meta-analysis. The book is well organized, is a pleasure to read, and is very well documented with up-to-date references." Hans C. Van Houwelingen for Bioometrics, September 2006

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Tilaustuote | Arvioimme, että tuote lähetetään meiltä noin 4-5 viikossa | Tilaa jouluksi viimeistään 27.11.2024
Myymäläsaatavuus
Helsinki
Tapiola
Turku
Tampere
The Evaluation of Surrogate Endpoints
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ISBN:
9780387202778
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