Timothy R. Rebbeck | Akateeminen Kirjakauppa

This volume comprises the investigation of factors that may predict the response to treatment, outcome, and survival by exploring:

• design considerations in molecular epidemiology, including:



case-only
family-based
approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics
incorporation of biomarkers in clinical trials

• measurement issues in molecular epidemiology, including



DNA biosampling methods
principles for high-quality genotyping
haplotypes
biomarkers of exposure and effect
exposure assessment

• methods of statistical inference used in molecular epidemiology, including



gene-gene and gene-environment interaction analysis
novel high-dimensional analysis approaches
pathway-based analysis methods
haplotype methods, dealing with race and ethnicity
risk models
a discussion of reporting and interpreting results

• A specific discussion and synopsis of these methods provides concrete examples drawn from primary research in cancer

Covering design considerations, measurement issues, and methods of statistical inference, and filled with scientific tables, equations, and pictures, Molecular Epidemiology: Applications in Cancer and Other Human Diseases presents a solid, single-source foundation for conducting and interpreting molecular epidemiological studies.