By collecting contributions of the many scientists who have interacted with Sergio Fubini and shared his friendship and enthusiasm for unraveling the ultimate mysteries of matter, this book offers a panorama of recent and interesting achievements in experimental and theoretical particle physics, gauge and string theories and the like. It also contains some reports about the historical development of this branch of activity, with its political, financial and cultural implications for the present and future. The common feature of the contributions is the search for symmetry and simplicity in complex phenomena. The book represents a struggle toward the future without forgetting the good and the bad of the past.