With the growth of combined clinical neurophysiology fellowship training programs and their corresponding “pan-physiology” board examinations, there has been an increased need for educational materials that span the range of clinical neurophysiology topics. The Clinical Neurophysiology Primer aims to meet this need by providing a broad and intentionally basic treatment of the most central topics within clinical neurophysiology. The Clinical Neurophysiology Primer initially took shape within the clinical neurophysiology sections at Beth Israel Deaconess Medical Center and Rhode Island Hospital, as an outgrowth of their fellowships’ didactic lecture series. Faculty and trainees at these and affiliated teaching hospitals participate in a series of lectures over the course of the academic year designed to acquaint trainees with the elements of clinical neurophysiology, supplementing their clinical experiences. We hope that this primer will prove valuable to others as a companion book intended for clinical neurophysiology fellows and neurology residents, to be used in conjunction with such a program of lectures.