The rapidly growing number of genomic data has had a profound impact on how bioinformatics is being taught to biologists. In the earlier days it was customary to lead the students gradually through all the concepts and tools, more recently this approach became less practicable because of the fast development of the field. The main body of this book consists of chapters summarizing the fundamental concepts of bioinformatics, based on the topics presented at a course held in Dubrovnik, Croatia, in 2003. The second part of the book contains application papers submitted by the students after the course.