Tekijä: Ronald T. Borchardt (ed.); Roger M. Freidinger (ed.); Tomi K. Sawyer (ed.); Philip L. Smith (ed.) Kustantaja: Springer (2010) Saatavuus: Noin 17-20 arkipäivää
Tekijä: Ronald Borchardt (ed.); Edward Kerns (ed.); Christopher Lipinski (ed.); Dhrien Thakker (ed.); Binghe Wang (ed.) Kustantaja: American Association of Pharmaceutical Scientists (2005) Saatavuus: Ei tiedossa
Tekijä: Ronald Borchardt (ed.); Edward Kerns (ed.); Michael Hageman (ed.); Dhrien Thakker (ed.); James Stevens (ed.) Kustantaja: Springer (2016) Saatavuus: Noin 17-20 arkipäivää
Springer Sivumäärä: 610 sivua Asu: Pehmeäkantinen kirja Julkaisuvuosi: 2010, 07.12.2010 (lisätietoa) Kieli: Englanti
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.