This curated collection of scientific papers on the origin and global spread of COVID-19 is a unique project that offers explanations at odds with mainstream views as the theme mainly focuses on Panspermia (viruses, microorganisms and their spores, and cometary arrival of even more complex cellular organisms).No other scientific group has paid attention to the temporal unfolding scientific order at the many required levels of understanding — astrobiological and astrophysical, geographical and the temporal order of global proportions, yet regional epidemics, the immunologic dimensions to the infection and epidemic data, the genetics of the SARS-CoV-2 virus as it adapted, varied and appeared in different human populations in the crucial first few months of the pandemic. This in-depth analysis, over a two-year period, allows a better understanding of what engulfed the world during the COVID-19 pandemic, how it happened and the most plausible way.There are many lessons for future generations that can be distilled from the contributions found in this book.