This book addresses James Joyce’s borderlessness and the ways his work crosses or unsettles boundaries of all kinds. The essays in this volume position borderlessness as a major key to understanding Joycean poiesis, opening new doors and new engagements with his work. Contributors begin by exploring the circulation of Joyce’s writing in Latin America via a transcontinental network of writers and translators, including José Lezama Lima, José Salas Subirat, Leopoldo Marechal, Eduardo Desnoës, Guillermo Cabrera Infante, and Augusto Monterroso. Essays then consider Joyce through the lens of the sciences, presenting theoretical interventions on posthumanist parasitology in Ulysses; on Giordano Bruno’s coincidence of opposites in Finnegans Wake; and on algorithmic agency in the Wake. Cutting-edge cognitive narratology is applied to the “Penelope” episode. Next, the volume features innovative essays on Joyce in relation to early animated film and comics, engaging with animated film in the “Circe” episode, Joyce’s points of contact with George Herriman’s cartoon strip Krazy Kat, and structural affinities between open-world gaming and Finnegans Wake. The final essays focus on abiding human concerns, offering new research on Joyce’s creative use of “spicy books”; a Lacanian consideration of “The Dead” alongside Katherine Mansfield’s “The Stranger” and Haruki Murakami’s “Kino”; and a meditation on Joyce’s uncertainties about the boundary between life and death. For Joyce, borders are problems—but ones that provided precious fodder for his art. And as this volume demonstrates, they encourage brilliant reflections on his work, from new scholars to leading luminaries in the field.