The papers in this volume were selected for presentation at the 16th Annual InternationalComputing and CombinatoricsConference (COCOON 2010), held duringJuly19-21,2010inNhaTrang,Vietnam.Previousmeetingsofthisconf- encewereheldinSingapore(2002),BigSky(2003),JejuIsland(2004),Kunming (2005), Taipei (2006), Alberta (2007), Dalian (2008) and New York (2009). COCOON 2010 provided a forum for researchers working in the areas of - gorithms, theory of computation, computational complexity, and combinatorics related to computing. In all, 133 papers were submitted from 40 countries and regions, of which 54 were accepted. Authors of the submitted papers were from Australia (10), Bangladesh (11), Belgium (1), Canada (23), Chile (1), China (20), Colombia (1), Czech Republic (6), Denmark (1), France (25), France(1), Germany (13), Greece (2), Hong Kong (7), Hungary (2), India (18), Indonesia (8),IslamicRepublicofIran(2),Ireland(1),Israel(6),Italy(6),Japan(31),- publicofKorea(4),Malaysia(1),TheNetherlands(2),NewZealand(2),Norway (3), Pakistan (1), Poland (1), Portugal (1), Russian Federation (3), Singapore (6), Slovakia (1), Spain (7), Sweden (2), Taiwan (19), Thailand (2), UK (2), USA (44), and Vietnam (15). The submitted papers wereevaluated by an internationalTechnical Program Committee (TPC). Each paper was evaluated by at least three TPC members, with possible assistance of the external referees, as indicated by the referee list found in the proceedings. Some of these 54 accepted papers will be selected for publication in a special issue of Algorithmica, Journal of Combinatorial - timization,and Discrete Mathematics, Algorithms, and Application under the standard refereeing procedure. In addition to the selected papers, the conf- ence also included two invited presentations by Manuel Blum (Carnegie Mellon University) and Oscar H. Ibarra (University of California Santa Barbara).