Matrix interference is an often unrecognized but common problem in pharmaceutical assays. Written to help analysts design precise experiments that answer fundamental questions about assay specificity, Matrix Interference in Bioanalytical Assays explains the principles and mechanisms of molecules causing matrix interference in analytical assays and describes how to identify and mitigate effects of matrix interference. Rich with instructive case studies, this practical, hands-on guide also suggests experimental designs to help analytical personnel alleviate matrix interference problems and increase assay accuracy.