HMG-CoA reductase inhibitors (statins) are established drugs for the
treatment of hypercholesterolemia. Furthermore, they induce regression
of vascular atherosclerosis as well as reduction of
cardiovascular-related morbidity and death in patients with and without
coronary artery disease. This book deals with statins which have
substantially altered the approach to therapy of atherosclerosis and its
sequelae. Emphasis is placed on the scientific background to the
discoveries and the development of the therapy, including an overview of
the current state of knowledge of the drugs. Clinical data are reviewed
extensively. This book not only provides the reader with valuable
information but also stimulates further research into the pathogenesis
of atherosclerosis and the mechanisms behind the action of effective
statins. It sets the stage for creative thinking among scientists of
many disciplines for the accomplishment of our ultimate goals in
treating atherosclerosis and its sequelae. This topical volume...