Hormone replacement is clearly indicated for the prevention and treatment of osteoporosis. Although its importance in treating this disease is no longer questioned, much remains to be fully understood about its effective application in practice. Drug Therapy for Osteoporosis examines what is known about the progress of osteoporosis and describes the impact of hormone replacement therapy. The author reviews the option for using SERMs as opposed to conventional HRT regimens, discusses not only the effectiveness of treatment but also the recommended duration, and provides clear guidelines on the laboratory evaluation of osteoporosis.