This text brings together mechanobiology theory, approaches, and applications in a format appropriate for readers with some mathematical and biological exposure. It begins by explaining fundamental mechanobiological principles in a sequential "ground up" approach that includes key terminology. Next, it identifies the in vivo mechanical environment of biological systems-highlighting areas of important research. Maintaining a focus on mechanobiology fundamentals, it includes example questions drawn from a variety of organ systems, lower organisms, and plants. This comprehensive resource includes example problems drawn from theory and applications in each chapter, as well as sections on experimental methods.