Evidence-based Medicine (EBM) has been proposed as the most significant intellectual advance in the process of clinical decision-making in the past decade. With more than 25,000 medical journals publishing 4 million articles a year, doctors are unable to cope with the information overload. The principles and practice of EBM show the way to bridge the gap between research and practice.This issue of Primary Care: Clinics in Office Practice contains two sections: 1) EBM Approach to Common Primary Care Problems, and 2) EBM Approach to Preventive Care. Dr. Fred Miser is an Associate Professor of Family Medicine at The Ohio State University College of Medicine and Public Health.Dr. John McConaghy is an Associate Professor of Clinical Family Medicine at The Ohio State University College of Medicine and Public Health.