In today’s evidence-based healthcare culture, child life specialists must demonstrate knowledge and skill not only in clinical care, but also in planning and evaluating the impact of their interventions—yet few resources exist to provide research skills and support for these practitioners. To adequately evaluate, improve, and innovate patient and family outcomes, it is essential that all providers understand the key inquiry pathways of research. Combining clinical examples and skills with candid advice from seasoned child life specialist researchers, this text scaffolds the concept of inquiry into feasible units of action. From identifying a clinical question to assembling a team, designing a project, collecting and analyzing data, and reporting on results, it guides students, professionals, and administrators in actively exploring and improving healthcare outcomes for patients and their families. Case examples from the authors’ own experiences as clinicians and researchers serve to demonstrate how to seamlessly translate clinical skills into those needed for success in research, ensuring that child life specialists remain active contributors to today’s research evidence on the needs of children and families during healthcare encounters.