The Fifth International Germ Cell Tumour Conference brings together clinicians and scientists and covers all aspects of the disease from basic tumour biology, genetics and pathology through to clinical management. This edition should be a useful reference to the proceedings for those involved in treating the disease. As well as including information on optimum treatment and trial results, this book provides a forum for the interaction of scientists and clinicians addressing relevant issues. In the search for the optimum trial design in the 21st century, the book begins with data on DNA repair and malignant cell adaptation to resist conventional therapies, moving to potential strategies to overcome that resistance. It should have most value for clinical specialists and researchers who treat testicular, ovarian or extragonadal germ cell tumours.