Latest developments in the neuroscience and science of learning have affirmed the theories of the late cognitive psychologist Professor Reuven Feuerstein. The theory of Mediated Learning Experience (MLE) and Structural Cognitive Modifiability (SCM), which have their genesis in the 1950s continue to make advances in its implementation science. This book aims to provide a compilation of works that synthesises the most up-to-date knowledge, research, and practice of MLE and its interventions which would guide the application of MLE with diverse learners of different stages of human development. Besides an emphasis on the culturally responsive use of the Feuerstein approach, this book also intends to offer substantive coverage of the application of MLE across different contexts and seeks to merge the current state of knowledge and chart research directions for researchers in the cognitive and social-emotional development of students’ learning.