Bohan Li (ed.); Lin Yue (ed.); Chuanqi Tao (ed.); Xuming Han (ed.); Diego Calvanese (ed.); Toshiyuki Amagasa (ed.) Springer (2023) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Bohan Li (ed.); Lin Yue (ed.); Chuanqi Tao (ed.); Xuming Han (ed.); Diego Calvanese (ed.); Toshiyuki Amagasa (ed.) Springer (2023) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Bohan Li (ed.); Lin Yue (ed.); Chuanqi Tao (ed.); Xuming Han (ed.); Diego Calvanese (ed.); Toshiyuki Amagasa (ed.) Springer (2023) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Wenjia Niu (ed.); Gang Li (ed.); Jiqiang Liu (ed.); Jianlong Tan (ed.); Li Guo (ed.); Zhen Han (ed.); Lynn Batten (ed.) Springer (2015) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Jun Zhao (ed.); Frank van Harmelen (ed.); Jie Tang (ed.); Xianpei Han (ed.); Quan Wang (ed.); Xianyong Li (ed.) Springer (2019) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Anwar P. P. Abdul Majeed (ed.); Jessnor Arif Mat-Jizat (ed.); Mohd Hasnun Arif Hassan (ed.); Zahari Taha (ed.); Han Li Choi Springer (2019) Saatavuus: Tilaustuote Kovakantinen kirja
Jun Zheng (ed.); Cheng Li (ed.); Peter Han Joo Chong (ed.); Weixiao Meng (ed.); Feng Yan (ed.) Springer (2020) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Tianyi Wang (ed.); Zhifeng Han (ed.); Yongheng Yang (ed.); Shouqing Wang (ed.); Kaimeng Li (ed.) Springer (2020) Saatavuus: Tilaustuote Kovakantinen kirja
Anwar P. P. Abdul Majeed (ed.); Jessnor Arif Mat-Jizat (ed.); Mohd Hasnun Arif Hassan (ed.); Zahari Taha (ed.); Han Li Choi Springer (2020) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Tianyi Wang (ed.); Zhifeng Han (ed.); Yongheng Yang (ed.); Shouqing Wang (ed.); Kaimeng Li (ed.) Springer (2021) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Ming Fan (ed.); Jukka Heikkilä (ed.); Hongxiu Li (ed.); Michael J. Shaw (ed.); Han Zhang (ed.) Springer (2017) Saatavuus: Tilaustuote Pehmeäkantinen kirja
Springer Sivumäärä: 488 sivua Asu: Kovakantinen kirja Painos: 2014 Julkaisuvuosi: 2014, 30.01.2014 (lisätietoa) Kieli: Englanti
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression.
On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function.
On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function invarious biological events.
