Risk assessment of chemicals represents an important step in avoiding health problems, but requires multiple fields in concert: biostatistics, modeling, pharmacology, and biology. Using an integrated framework, the book explains these issues, how they affect the practice of risk assessment, and their applications to risk assessment of food and environmental contaminants. By connecting all of these areas in one book, the authors provide pharmacokinetic and risk assessment modelers with a one-stop reference manual on toxicokinetic risk assessment, showing how information acquired from each area contributes to meaningful risk assessment.