During the 1930s a new approach to exploring human consciousness began at Duke University with Professor J. B. Rhine's experimental research on extra-sensory perception, or ESP. His findings on telepathy, clairvoyance, precognition and psychokinesis challenged conventional disbelief. Rhine's findings and his first popular book, New Frontiers of the Mind, ignited excitement and controversy—among not only scientists but the public at large.

Rhine's letters chronicle his efforts to find reliable evidence of psychic ability, from the seance room to psychic animals and finally to a university research laboratory.

Covering the years 1923-1939, they reveal a gripping story of groundbreaking research, told in the words of the main player as he worked with his team, subjects, critics and supporters alike.