This book constitutes the refereed post-conference proceedings of the Second International Conference on Innovations and Interdisciplinary Solutions for Underserved Areas, InterSol 2018, and the 7th Collogue National sur la Recherche en Informatique et ses Applications, CNRIA 2018, held in Kigali, Rwanda, in March 2018. The 23 papers presented were selected from 56 submissions and issue the following themes: papers dealing with the evolution of performances of solar systems in Africa, papers addressing the issues is public health, telecom papers studying the business model of telecommunication, math models presenting the climatic phenomenon and finally health papers dealing with medical devices that are suitable to underserved areas. The proceedings also contain 7 papers from the co-located 7th CNRIA (Collogue National sur la Recherche en Informatique et ses Applications) focusing on network architecture and security, software engineering, data management, and signal processing.