This volume, the 35th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains five fully-revised selected regular papers focusing on data quality, social-data artifacts, data privacy, predictive models, and e-health. Specifically, the five papers present and discuss a data-quality framework for the Estonian public sector; a data-driven approach to bridging the gap between the business and social worlds; privacy-preserving querying on privately encrypted data in the cloud; algorithms for the prediction of norovirus concentration in drinking water; and cloud computing in healthcare organizations in Saudi Arabia.