This volume represents the proceedings of the conference on Noncommutative Geometric Methods in Global Analysis, held in honor of Henri Moscovici, from June 29-July 4, 2009, in Bonn, Germany. Henri Moscovici has made a number of major contributions to noncommutative geometry, global analysis, and representation theory. This volume, which includes articles by some of the leading experts in these fields, provides a panoramic view of the interactions of noncommutative geometry with a variety of areas of mathematics. It focuses on geometry, analysis and topology of manifolds and singular spaces, index theory, group representation theory, connections of noncommutative geometry with number theory and arithmetic geometry, Hopf algebras and their cyclic cohomology.