In this issue of Emergency Medicine Clinics, guest editors Drs. George Willis and Bennett A. Myers bring their considerable expertise to the topic of Endocrine and Metabolic Emergencies. Endocrine and metabolic emergencies, both those that are commonly encountered in day-to-day emergency medicine and those that are rarely seen, can result in serious complications that can be life-threatening if not recognized, diagnosed, and appropriately managed. In this issue, top experts in the field cover key topics such as diabetic ketoacidosis; hyperosmolar hyperglycemic state; disorders of sodium and potassium; hypoglycemia; and more.