In this issue of Infectious Disease Clinics of North America, guest editors Dr. Daniel A. Solomon and Paul E. Sax bring their considerable expertise to the topic of Advances in the Management of HIV. Top experts in the field review the state of the art in HIV treatment and prevention, discuss challenges and opportunities in reaching especially vulnerable populations, identify treatment challenges in an aging population, and look into the future of antiretroviral therapy, vaccine development, and training the next generation of the HIV workforce.