Projects with different levels of intervention are producing changes in two of America’s Rust-Belt cities; the steel city of Pittsburgh and the iconic motor city of Detroit. Architecture is determining new spaces, uses and forms, mainly by engaging the remodelling of structural skeletons and architectural materials, as well as assets found in a context marked by the post-industrial crisis. Through the narration of several case studies, it is possible to reflect on the current role played by projects and architects in redefining a different production system for living, working and playing.