In this issue of Hematology/Oncology Clinics, guest editors Drs. Kevin M. Elias, Ross S. Berkowitz, Antonio Braga, and Neil S. Horowitz bring their considerable expertise to the topic of Gestational Trophoblastic Neoplasia. Top experts share their knowledge and experience with these rare malignancies, reviewing how to correctly diagnose these tumors, select options for chemotherapy or surgical management, follow patients for common complications of therapy, and attend to unique issues related to this family of diseases.