This classic single-author text has been extensively revised and updated. As in previous editions it provides a comprehensive review of cognitive, emotional and behavioural consequences of cerebral disorder and their manifestations in clinical practice. In addition to standard neuropsychiatric conditions, the subject matter encompasses endocrine, metabolic and toxic disorders with respect to their impact on brain function. Extensive new sections have been added to take into account recent theoretical and clinical developments, particularly in chapters on dementias and toxic disorders, and in reference to the expanding range of rarer neurodegenerative disorders. The problems of HIV infection receive extensive coverage as well as the accumulating evidence pointing to a neuropsychiatric basis for schizophrenia. Advances in brain imaging are detailed as are salient discoveries in the fields of molecular biology and molecular genetics. Finally, many new references have been added.