Tekijä: Cindy Talbott Roché; Richard Brainerd; Barbara L. Wilson; Nick Otting; Robert C. Korfhage Kustantaja: Oregon State University (2019) Saatavuus: Ei tiedossa
Tekijä: Sam S.Y. Wang; Patrick J. Roche; Richard A. Schmalz; Yafei Jia Kustantaja: American Society of Civil Engineers (2009) Saatavuus: Noin 17-20 arkipäivää
Tekijä: Richard Roche; Sean Commins; Francesca Farina Kustantaja: Taylor & Francis Ltd (2018) Saatavuus: | Arvioimme, että tuote lähetetään meiltä noin 1-3 viikossa
Tekijä: C. Richard Goldfarb; Murthy R. Chamarthy; Fukiat Ongseng; Steven R. Parmett; David L. Bushnell; Rosna Mirtcheva-Trocheva Kustantaja: Thieme Medical Publishers Inc (2018) Saatavuus: Noin 17-20 arkipäivää
Humana Press Inc. Sivumäärä: 750 sivua Asu: Kovakantinen kirja Painos: 2005 Julkaisuvuosi: 2005, 15.04.2005 (lisätietoa) Kieli: Englanti
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.