The idea that the immune system may play a role in protecting against malignant disease is not new. Since the earliest days of immunology research, scientists have sought to understand the mechanisms by which the host immune system might recognise cancer cells, and to manipulate these responses for therapeutic gain. It has become clear that the key to immune recognition of tumours lies in the relationship between cells in the microenvironment of the tumour itself.
This volume provides a comprehensive collection of techniques for establishing tumour cell lines, testing their immunogenicity, and characterising the major effector cells, leading to protocols for manipulating antibody and T-cell receptor structure, preparing cytokine-secreting tumour cells and testing the efficiency of these new agents in preventing tumour growth. Researchers in immunology as a whole in addition to those interested in cancer immunology will find Tumour Immunobiology: A Practical Approach to be an invaluable practical resource.
