High Performance Scienti?c Computing is an interdisciplinary area that combines many ?elds such as mathematics, computer science and scienti?c and engineering applications. It is a key high-technology for competitiveness in industrialized countries as well as for speeding up development in emerging countries. High performance scienti?c computing develops methods for c- puteraidedsimulationandoptimizationofsystemsandprocesses.Inpractical applications in industry and commerce, science and engineering, it helps to save resources, to avoid pollution, to reduce risks and costs, to improve pr- uctquality,toshortendevelopmenttimesorsimplytooperatesystemsbetter. Di?erent aspects of scienti?c computing have been the topics of the Third International Conference on High Performance Scienti?c Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Ho Chi Minh City University of Te- nology, Interdisciplinary Center for Scienti?c Computing (IWR), Heidelberg, and its International PhD Program "Complex Processes: Modeling, Simu- tion and Optimization". The conference had about 200 participants from countries all over the world.Thescienti?cprogramconsistedofmorethan130talks,10ofthemwere invited plenary talks given by John Ball (Oxford), Vincenzo Capasso (Milan), PaoloCarloni(Trieste),SebastianEngell(Dortmund),DonaldGoldfarb(New York), Wolfgang Hackbusch (Leipzig), Satoru Iwata (Tokyo), Hans Petter Langtangen (Oslo), Tao Tang (Hong Kong) and Philippe Toint (Namur).